Disney's The Buzz on Maggie is an animated comedy that takes viewers into the daily life of Maggie Pesky, a spunky and unique tween fly living in Stickyfeet, a conventional fly world. Looking for a way to make her mark, she embodies individuality with inspired antics that often ruffle the antennae of the world around her.

Maggie's adventures often involve the aid of her best friend and sassy side-kick Rayna. More often than not, her antics bug at least one member of her family which includes: her parents, Mr. and Mrs. Pesky; her older brother Aldrin, a football player and big fly on campus; her wide-eyed younger brother Pupert and her adorable baby sister Bella.

The series stars Jessica DiCicco (Bratz) as Maggie Pesky; David Kaufman (Stuart Little television series) as Aldrin Pesky; Thom Adcox (American Dragon: Jake Long) as Pupert Pesky; Cree Summer (The Proud Family) as best friend Rayna; Brian Doyle Murray (Snow Dogs) as Maggie's father and Susan Tolsky (Pepper Ann) as Maggie's mother.

Other cast members are: Tara Strong (The Proud Family) as Maggie's nemesis Dawn Swatworthy; Jeff Bennett (American Dragon: Jake Long) as sneaky yet clever Principal Peststrip; Curtis Armstrong (Ray) as Maggie's pompous and short-tempered teacher Mr. Bugspit; and Candi Milo (W.I.T.C.H.) as the gruff, no-nonsense science teacher Mrs. Wingston.